These reactions may include bloating, anxiety, nausea, constipation, and sleeplessness along with making you all sweaty and jittery. The xanthine derivatives are agents that resemble natural occurring xanthines such as caffeine, theobromine and methylxanthines. What are the three main physiological effects produced by xanthines? It has a relaxing effect on bronchial smooth muscles. Xanthine is found to be associated with Lesch-Nyhan syndrome and xanthinuria type 1, which are inborn errors of metabolism. Cautions. It is worth noting that members of this series lack the carboxylic acid to interact with Arg111 of GPR109A, unlike compounds in the aforementioned series. Therefore, monitoring for nontoxic levels is necessary. Xanthine derivatives have been used in allergic asthma for their bronchodilatory and anti-inflammatory properties; however, these agents have multiple side effects. The publications reveal no age-dependent increase in side effects for febuxostat. Stimulates breathing and has a high therapeutic index with fewer side effects than theophylline. Hypersensitivity to xanthine derivatives, porphyria. See "What Are Side Effects Associated with Using Zaditen?" Uses and Benefits of Doxofylline: Concomitant treatment with xanthine derivatives, steroids, or diuretics may potentiate any hypokalemic effect of formoterol Use with caution in patients taking non-potassium-sparing diuretics, as the ECG changes and/or hypokalemia may worsen with concomitant beta 2 -agonists The functional role of Doxofylline is similar to that of Theophylline but with fewer side-effects. The incidence of severe side effects was much less frequent than mild side effects (1.2–3.8% to 20.1–38.7%). Short-Term Effects. It is … Nursing considerations Assessment. The frequency and severity of side effects depend on many factors including dose, duration of therapy, and individual susceptibility. The active ingredient in the drug is the compound Doxofylline that is a Xanthine derivative. Effects of xanthine derivatives on electroretinographic responsiveness. The chemical formula of Doxofylline is C11H14N4O4. 57. zgaga@helix.nih.gov Smoking cigarettes or other tobacco products may markedly influence the effects of theophylline. Are There Any PX Pro Xanthine Side Effects? Ask your health care provider if thiabendazole may interact with other medicines that you take. The product, however, causes extreme allergic reactions in some cases. Many xanthine bronchodilator users experience no, or minor, side effects, particularly if serum theophylline levels are less than 20 mcg/mL. Long-Term Effects. The vasodilation caused by xanthines has been used to treat intermittent claudication (pentoxifylline). See "What Are Side Effects Associated with Using Zaditen?" A xanthine series (I) exemplified by 33 and 34 is another important class of GPR109A agonists [83–88]. Andjus RK(1), Konjević D, Damjanović I, Gacić Z. Xanthines also stimulate muscle and cardiac cells and neurons. Xanthine derivatives (eg, theophylline) because side effects, including risk of nausea, vomiting, heart problems, or seizures, may be increased by thiabendazole; This may not be a complete list of all interactions that may occur. The rate and range of febuxostat side effects are low at doses of up to 120 mg and only increase with a daily dose of over 120 mg. Yes! 5.7 Xanthine derivatives. Why is theophylline classified as a bronchodilator? The molar mass of the compound is 266.25 g/mol. Traditional asthma medications such as theophylline have less of a role in the treatment of pure exercise-induced asthma. These contain theophylline-related substances that may increase your side effects. In patients with Author information: (1)Center for Multidisciplinary Studies, University of Belgrade, 29 Novembra 142, 11000, Belgrade, Yugoslavia. 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